Hyperbranched Ketone Thioglycol Polyethylene Glycol Acrylate (HBPAK)

Hyperbranched ketithiolide polyethylene glycol acrylate (HBPAK) is a hyperbranched polymer obtained through a Michael addition reaction between ketithiolide diamine (TK) and polyethylene glycol diacrylate (PEGDA). This material not only inherits the reactive oxygen species (ROS) responsiveness of ketithiolides, but its unique hyperbranched topology also endows it with functions such as a crosslinking agent and drug carrier. In biomedical applications, HBPAK is commonly used as a structural component of hydrogels or microgels to scavenge excess ROS generated after tissue damage, thereby reducing inflammation and providing a new material option for the treatment of diseases such as myocardial infarction and stroke. The ketithiolide diamine units abundant in the HBPAK structure can specifically respond to reactive oxygen species (ROS) in the skin microenvironment, achieving intelligent release or structural reconstruction, precisely targeting oxidative stress areas. With polyethylene glycol as its backbone, it possesses excellent water solubility and biocompatibility; its hyperbranched structure endows it with high capacity for loading active substances and stability.
• One-step reaction synthesis, mild process, no toxic byproducts, and controllable purity of raw materials.

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