JC-1

- Overview
  - JC-1 (5,5′,6,6′-Tetrachloro-1,1′,3,3′-tetraethylbenzimidazolylcarbocyanine chloride) is a mitochondrial dye that stains mitochondria in living cells in a membrane potential-dependent fashion. JC-1 exists as a monomer at low concentrations and yields green fluorescence, similar to fluorescein. At higher concentrations, the dye forms J-aggregates that exhibit a broad excitation spectrum and an emission maximum at ~590 nm. These characteristics make JC-1 a sensitive marker for mitochondrial membrane potential. JC-1 is particularly useful for apoptosis studies. In apoptotic cells, the dye stays in the cytoplasm and fluoresces green.
    
    Please contact us at for specific academic pricing.
    
    More Details
    
    EasyProbe™ Cell Structure Probes
- Properties
  - Categories
    
    Mitochondria stains
    
    Molecular Weight
    
    652.23
    
    Other Properties
    
    Excitation/Emission (nm): 514/529;585/590
    
    Storage
    
    2-8°C, protect from light
    
    Shipping
    
    Ambient
    
    * For research use only
- Applications
  - Application
    
    Mitochondria labeling
- Reference
  - A water soluble CoQ10 formulation improves intracellular distribution and promotes mitochondrial respiration in cultured cells. Bergamini C, Moruzzi N, Sblendido A, Lenaz G, Fato R, PLoS One (2012) 7:e33712-e33712
    SOD2 contributes to anti-oxidative capacity in rabbit corneal endothelial cells. Liu C, Ogando D, Bonanno JA, Mol Vis (2011) 17:2473-2481
    Saikosaponin-d Enhances the Anticancer Potency of TNF-a via Overcoming Its Undesirable Response of Activating NF-Kappa B Signalling in Cancer Cells. Wong VK, Zhang MM, Zhou H, Lam KY, Chan PL, Law CK, Yue PY, Liu L, Evid Based Complement Alternat Med (2013) 2013:745295-745295

MSDS

Documents

Protocol-C045

COA-C045

JC-1

More Details

Documents

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