Imatinib Mesylate

- Overview
  - Imatinib mesylate is a tyrosine kinase inhibitor used primarily in the treatment of leukemia. Chronic Myeloid Leukemia (CML) cells contain a hybrid tyrosine kinase BCR/ABL that works to provide the cancer cell with ATP at an uncontrolled rate. Imatinib mesylate inhbiits this hybrid protein to slow cell growth and promote apoptosis.
    
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    Background
    
    Imatinib mesylate binds to the ATP binding site of the BCR/ABL tyrosine kinase and stabilizes its inactive form.
- Properties
  - CAS Number
    
    220127-57-1
    
    Molecular Formula
    
    C29H31N7O•CH3SO3H
    
    Molecular Weight
    
    589.71
    
    Appearance
    
    White to off-white solid
    
    Storage
    
    2-8°C
    
    * For research use only