Name: IGFBP-3 peptide
Price: 314.00 USD

- Overview
  - Blocks ?haluronan-CD44 signaling.
    IGFBP-3 peptide is a peptide derived from the nuclear localization sequence within the heparin-binding domain of insulin like growth factor binding protein-3 (IGFBP-3), and corresponds to amino acids 215-232 of the full-length protein. Both this region and IGFBP-3 peptide bind to glycosaminoglycans including hyaluronan, and also have high affinity and specificity for the mitochondria derived peptide humanin, binding to it with a with a Kd of 120 nM compared with binding of 101 nM for the full-length protein. Both the IGFBP-3 protein and the synthetic IGFBP-3 peptide bind to hyaluronic acid and block its ability to interact with its receptor CD44, and using the synthetic IGFBP-3 peptide to bind hyaluronan inhibits viability of A549 lung cancer cells, an effect correlated with increased apoptosis.
    
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- Properties
  - Categories
    
    Peptides
    
    Alternative Name
    
    215-KKGFYKKKQCRPSKGRKR-232
    
    Molecular Formula
    
    C98H172N36O21S
    
    Molecular Weight
    
    2221.32
    
    Appearance
    
    Freeze dried solid
    
    Purity
    
    >95% by HPLC
    
    Solubility
    
    Soluble in water
    
    Other Properties
    
    Sequence: H-Lys-Lys-Gly-Phe-Tyr-Lys-Lys-Lys-Gln-Cys-Arg-Pro-Ser-Lys-Gly-Arg-Lys-Arg-NH2,KKGFYKKKQCRPSKGRKR-NH2
    Modification: C terminal amide
    
    Storage
    
    Store dry, frozen and in the dark
    
    * Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

IGFBP-3 peptide

IGFBP-3 peptide

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