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Overview
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N-terminal fragment of the interphotoreceptor retinoid binding protein (IRBP).
IRBP (1-20) (human) is the 1 to 20 amino acid N-terminal fragment of the interphotoreceptor retinoid binding protein (IRBP). IRBP, also known as retinol binding protein-3 (RBP-3), is a 1264 amino acid residue glycolipoprotein residing in the interphotoreceptor matrix where it is the major extracellular retinoid-binding protein. IRBP is often the target of autoimmune attack and this is one of the leading causes of uveitis. IRBP peptide (1-20) (human) contains a major epitope for the H-2b haplotype and immunization with IRBP (1 20) (human) induces T-cell mediated experimental autoimmune uveoretinitis (EAU), a widely used rodent model of human disease.
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Overview