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Human TLR9 full length protein-synthetic nanodisc

Human TLR9 full length protein-synthetic nanodisc

Catalog Number:
P001561754DIM
Mfr. No.:
FLP100146
Price:
$1,013
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      • Overview

        • Target: TLR9
          Tag: C-Flag Tag
          Synonyms: CD289
          Protein Families: Druggable Genome, Transmembrane
          Protein Pathways: Toll-like receptor signaling pathway

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          Background

          The protein is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response.

      • Properties
        • Type
          Synthetic Nanodiscs
          Conjugate
          Unconjugated
          Formulation
          Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments.
          Storage
          Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
          Molecular Weight
          The human full length TLR9 protein has a MW of 115.9 kDa
          Expression system
          HEK293

          More Information

          UniProt
          Q9NR96

          * For research use only.

    MSDS

    Documents

    Datasheet

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