Human STING1 full length protein-synthetic nanodisc

Human STING1 full length protein-synthetic nanodisc

Catalog Number:
P001561702DIM
Mfr. No.:
FLP100040
Price:
$1,013
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      • Overview

        • Target: STING1
          Tag: C-Flag Tag
          Synonyms: ERIS; hMITA; hSTING; MITA; MPYS; NET23; SAVI; STING; STING-beta; TMEM173
          Protein Families: Transmembrane
          Protein Pathways: Cytosolic DNA-sensing pathway, RIG-I-like receptor signaling pathway

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          Background

          A five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants.

      • Properties
        • Type
          Synthetic Nanodiscs
          Conjugate
          Unconjugated
          Formulation
          Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments.
          Storage
          Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
          Molecular Weight
          The human full length STING1 protein has a MW of 42.2 kDa
          Expression system
          HEK293

          More Information

          UniProt
          Q86WV6

          * For research use only.

    MSDS

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    Datasheet

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