HUMAN IG/TCR DNA MULTIPLEX kit (7GENES)

The HUMAN IG/TCR DNA MULTIPLEX kit (7GENES) is designed for the simultaneous repertoire profiling of all human adaptive immune receptor genes (immune adaptome), including TRA, TRB, TRG, TRD, IGH, IGK, and IGL, in a single assay, starting from DNA. The kit contains a multiplex primer set covering complete (all functional and rearrangeable non-functional) and incomplete V(D)J rearrangements of IG and TCR loci. The primer structures, concentrations, and other PCR conditions have been adjusted to minimize offtarget amplification and quantitative bias, allowing accurate and sensitive IG and TCR clonotypes diversity assessment.
The kit is designed for 96 IG/TCR libraries starting from 96 DNA samples.
DNA (or cDNA) obtained from any kind of source, including whole blood (venous and capillary), PBMC, separated B and T cell subsets, FFPE blocks (depending on DNA fragmentation), bone marrow, tissue biopsies, and tumor fragments can be used as input material. The 7GENES kit applies for lymphoid malignancy clonality detection and the conventional MRD (minimal residual disease) monitoring approach. The libraries obtained using the 7GENES kit can be sequenced on any Illumina instruments in PE150 or SE150 mode.

MiXCR is a universal solution for fast and rigorous extraction and analysis of T-cell and B-cell receptor repertoire high-throughput sequencing data.

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