Human CLDN4 full length protein-synthetic nanodisc

Human CLDN4 full length protein-synthetic nanodisc

Catalog Number:
P001561740DIM
Mfr. No.:
FLP100083
Price:
$1,013
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      • Overview

        • Target: CLDN4
          Tag: C-Flag Tag
          Synonyms: CPE-R; CPER; CPETR; CPETR1; hCPE-R; WBSCR8
          Protein Families: Druggable Genome, Transmembrane
          Protein Pathways: Cell adhesion molecules (CAMs), Leukocyte transendothelial migration, Tight junction

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          Background

          The protein belongs to the claudin family. Claudins are integral membrane proteins that are components of the epithelial cell tight junctions, which regulate movement of solutes and ions through the paracellular space. This protein is a high-affinity receptor for Clostridium perfringens enterotoxin (CPE) and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems.

      • Properties
        • Type
          Synthetic Nanodiscs
          Conjugate
          Unconjugated
          Formulation
          Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments.
          Storage
          Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
          Molecular Weight
          The human full length CLDN4 protein has a MW of 22.1 kDa
          Expression system
          HEK293

          More Information

          UniProt
          O14493

          * For research use only.

    MSDS

    Documents

    Datasheet

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