Human ADGRE1 full length protein-synthetic nanodisc

Human ADGRE1 full length protein-synthetic nanodisc

Catalog Number:
P001561722DIM
Mfr. No.:
FLP100055
Price:
$1,013
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      • Overview

        • Target: ADGRE1
          Tag: C-Flag Tag
          Synonyms: EMR1; TM7LN3
          Protein Families: Druggable Genome, Transmembrane

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          Background

          This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The encoded preproprotein is proteolytically processed to generate the mature protein, which promotes cholesterol efflux from tissues to the liver for excretion, and is a cofactor for lecithin cholesterolacyltransferase (LCAT), an enzyme responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein. [provided by RefSeq, Dec 2015]

      • Properties
        • Type
          Synthetic Nanodiscs
          Conjugate
          Unconjugated
          Formulation
          Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments.
          Storage
          Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
          Molecular Weight
          The human full length ADGRE1 protein has a MW of 97.5 kDa
          Expression system
          HEK293

          More Information

          UniProt
          Q14246

          * For research use only.

    MSDS

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    Datasheet

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