Human SLC7A11 full length protein-synthetic nanodisc

Human SLC7A11 full length protein-synthetic nanodisc

Catalog Number:
P001561725DIM
Mfr. No.:
FLP100048
Price:
$1,013
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      • Overview

        • Target: SLC7A11
          Tag: C-Flag Tag
          Synonyms: CCBR1; xCT
          Protein Families: Druggable Genome, Transmembrane

          Please contact us at for specific academic pricing.

          Background

          This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death. [provided by RefSeq, Sep 2011]

      • Properties
        • Type
          Synthetic Nanodiscs
          Conjugate
          Unconjugated
          Formulation
          Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments.
          Storage
          Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
          Molecular Weight
          The human full length SLC7A11 protein has a MW of 55.4 kDa
          Expression system
          HEK293

          More Information

          UniProt
          Q9UPY5

          * For research use only.

    MSDS

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    Datasheet

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