Name: HQNO
Price: 207.00 USD

- Overview
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    Background
    
    HQNO is a NADH oxidase inhibitor. The NADPH oxidase, a membrane-bound enzyme complex facing the extracellular space, can be found in the plasma membrane and in the membranes of phagosomes used by neutrophil white blood cells to engulf microorganisms. Isoforms are designated NOX1, NOX2, NOX3, as well as NOX4.In vitro: Previous study found that HQNO could inhibit the Na+-dependent NADH oxidase but had very limited effect on the NA+-independent activity of mutant membranes. Moreover, the NADH:quinone oxidoreductase was observed to be the Na+-dependent HQNO-sensitive site of the NADH oxidase. In addition, HQNO was found to be able to cause a strong inhibition of the Na+ pump with limited effect on the overall H+ extrusion by respiration in the wild type cells. The inhibition of the Na+ pump by HQNO could be overcome by oxidized but not reduced TMPD. The electron flow NADH to oxygen appeared to bypass the HQNO-sensitive site and energize the Na+ pump in the presence of oxidised TMPD [1].In vivo: Up to now, there is no animal in vivo data reported.Clinical trial: So far, no clinical study has been conducted.
- Properties
  - Alternative Name
    
    KF8940,N-oxo-2-heptyl-4-Hydroxyquinoline,Pyo II; 2-heptyl-1-hydroxyquinolin-4(1H)-one
    
    CAS Number
    
    341-88-8
    
    Molecular Formula
    
    C16H21NO2
    
    Molecular Weight
    
    259.34
    
    Purity
    
    99.75%
    
    Solubility
    
    ≥25.9 mg/mL in ETOH with gentle warming; insoluble in H2O; ≥2.48 mg/mL in DMSO with gentle warming and ultrasonic
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

HQNO

HQNO

Background

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