Name: Oxy-16
Price: 287.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    Oxy-16 is an antagonist of hedgehog activity.
    Naturally occurring oxysterols that are products of cholesterol oxidation can stimulate the hedgehog (Hh) signaling pathway related to cardiovascular disease and bone formation. Activation of Hh signaling modulates inflammatory responses to additional atherogenic factors including lesion-producing macrophages and enable osteoblast differentiation, which is dependent on the target cell.
    In vitro: Oxysterols have been shown to be associated with immunosuppression, apoptosis, atherosclerosis, inflammation, and cholesterol turnover. Other studies aslo indicated that oxysterols were Hedgehog (Hh) signaling pathway activators and had potent osteoinductive properties. Oxy-16, an oxysterol, was identified as a cell permeable oxygenated derivative of cholesterol that might be the end product or intermediate of the cholesterol excretion pathways. Oxy-16 is currently used as a transport form for cholesterol across the blood brain barrier and membranes. The osteogenic differentiation caused by Oxy-16 was cinsidered to be mediated via a Wnt signaling-related, Dkk-1-inhibitable mechanism [1].
    In vivo: Up to now, there is no animal in vivo data reported.
    Clinical trial: So far, no clinical study has been conducted.
- Properties
  - Categories
    
    antagonist of hedgehog activity
    
    Alternative Name
    
    20(R),22(R)-dihydroxy Cholesterol; cholest-5-ene-3b,20,22R-triol
    
    CAS Number
    
    596-94-1
    
    Molecular Formula
    
    C27H46O3
    
    Molecular Weight
    
    418.7
    
    Appearance
    
    A crystalline solid
    
    Purity
    
    Purity ≥ 95.00%
    
    Solubility
    
    ≤10mg/ml in ethanol;1.5mg/ml in DMSO;1.5mg/ml in dimethyl formamide
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    O[[email protected]](C1)CC[[email protected]@]2(C)C1=CC[[email protected]]3([H])C2CC[[email protected]@]4(C)[[email protected]@]3([H])CC[[email protected]]4([H])[[email protected]@](C)(O)[[email protected]](O)CCC(C)C
    
    * For Research Use Only

Documents

COA (Certificate Of Analysis)

MSDS (Material Safety Data Sheet)

Oxy-16

Oxy-16

Background

Documents

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