Name: CUR 61414
Price: 287.00 USD

- Overview
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    Background
    
    IC50: 100-200 nM for hedgehog-induced cellular activityCUR 61414 is a potent inhibitor of hedgehog-induced cellular activity.The link between basal cell carcinoma (BCC) and aberrant activation of the Hedgehog (Hh) signaling pathway has been well established in humans and in mouse models.In vitro: Previous study found that CUR61414 was able to arrest proliferation of basal cells within the BCC-like lesions and induce cells to undergo apoptosis resulting in complete regression of the lesions, without affecting neighboring skin cells [1].In vivo: The efficacy of CUR61414 against basaloid lesions induced when mice were exposed to UV light. These mice were UV irradiated for 6-9 months, producing many microscopic BCC-like basaloid lesions throughout their skin. Results showed that the treatment with CUR61414 could cause regression of these lesions, as demonstrated by both X-gal staining and histological analyses. Moreover, the regression in the CUR61414-treated mice seemed to be the result of massive cell death, becuase a significant increase in apoptotic nuclei was seen in basaloid nests after treatment. In addition, no overt toxicity was observed in the skin surrounding the lesions [1].Clinical trial: So far, no clinical study has been conducted.
- Properties
  - Alternative Name
    
    G-856; N-[(3S,5S)-1-(1,3-benzodioxol-5-ylmethyl)-5-(1-piperazinylcarbonyl)-3-pyrrolidinyl]-N-[(3-methoxyphenyl)methyl]-3,3-dimethyl-butanamide
    
    CAS Number
    
    334998-36-6
    
    Molecular Formula
    
    C31H42N4O5
    
    Molecular Weight
    
    550.7
    
    Appearance
    
    A crystalline solid
    
    Purity
    
    98.00%
    
    Solubility
    
    ≤10mg/ml in ethanol;10mg/ml in DMSO;10mg/ml in dimethyl formamide
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

CUR 61414

CUR 61414

Background

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