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GSK215

GSK215

Catalog Number:
PTC1441521INV
Mfr. No.:
V60079
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      • Overview

        • GSK215 is a potent and selective PROTAC adhesion kinase (FAK) degrader, pDC50 The value is 8.4. GSK215 was designed in conjunction with VHL E3 ligase binder and FAK inhibitor VS-4718. GSK215 induces rapid and persistent degradation of FAK, with long-term effects on FAK levels and a significant reduction in pharmacokinetics/pharmacodynamics.

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      • Properties
        • Categories
          PROTACs
          CAS Number
          2743427-26-9
          Molecular Formula
          C50H59F3N10O6S
          Molecular Weight
          985.13
          Purity
          ≥98%
          Storage
          Powder: store in -20°C freezer for up to three years, store in 4°C freezer for up to two years
          In solvent: store in -80°C freezer for up to six months, store in -20°C freezer for up to two months
          Shipping
          Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
          SMILES
          N(C1C=CC=CC=1C(=O)NC)C1=CC(NC2C=CC(N3CCN(CC(=O)N[C@@H](C(C)(C)C)C(N4C[C@H](O)C[C@H]4C(=O)N[C@H](C4C=CC(C5SC=NC=5C)=CC=4)C)=O)CC3)=CC=2OC)=NC=C1C(F)(F)F

          * For research use only

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