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Overview
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Griseofulvin is a natural antifungal discovered in 1939 from Penicillium griseofulvum. It is fungistatic against species causing ringworm (Microsporum, Epidermophyton, and Trichophyton). It can bind to tubulin and interfere with mitosis. It can induce apoptosis in human tumor cell lines, showing promise as an anti-cancer agent. Griseofulvin is insoluble in water.
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Background
The mechanism of action of Griseofulvin is not well described, but is currently thought to bind to tubulin and interfere with mitosis. In addition, Griseofulvin is thought to inhibit synthesis of nucleic acids. It is able to induce apoptosis in human tumor cell lines.
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