Norfloxacin

- Overview
  - Norfloxacin is a first-generation synthetic fluoroquinolone antibiotic.
    
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    Background
    
    Norfloxacin indirectly inhibits DNA gyrase by binding to nearby DNA substrate. DNA gyrase is an essential DNA replication enzyme which reduces DNA strain during active DNA replication. Norfloxacin is most active in the pH range between 4.5 and 6.5.
- Properties
  - CAS Number
    
    70458-96-7
    
    Molecular Formula
    
    C16H18FN3O3
    
    Molecular Weight
    
    319.33
    
    Appearance
    
    White to light-yellow crystalline powder
    
    Solubility
    
    Acetone: 5.1 mg/mL
    Chloroform: 5.5 mg/mL
    Water: 0.28 mg/mL
    Acids and bases: Soluble at pH <5 and >10
    
    Other Properties
    
    Source: Synthetic
    Assay: (On Dried Basis): 99.0-101.0%
    Loss on Drying: ≤1.0%
    Melting Point: 220-221°C
    
    Storage
    
    2-8°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Norfloxacin is a broad spectrum antibiotic commonly used to target bacteria responsible for urinary tract infections.
    
    Microbiology Applications: Norfloxacin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include: Escherichia coli 0.25 µg/mL – 10 µg/mL Media Supplements: Norfloxacin can be used as a selective agent in several types of isolation media: Clostridium difficile Agar - CDMN Selective Supplement