Name: GQ1b-Ganglioside ammonium
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- Overview
  - GQ1b ganglioside (ammonium salt) has a core tetrasaccharide structure (Galβ1,3GalNAcβ1,4Galβ1,4Glc) with two sialic acids (NeuAc) linked α2,3/α2,8 to the inner galactose residue, two sialic acids (NeuAc) linked α2,3/α2,8 to the terminal galactose residue, and ceramide linked β to position 1 on the reducing terminal glucose residue (Ledeen, 2009). Anti-GQ1b ganglioside antibody is associated with Miller Fisher syndrome and is also found in patients with related conditions that may share the same pathogenic mechanism, such as, Bickerstaff brainstem encephalitis. Thus, the measurement of anti-GQ1b antibody in suspected cases of Miller Fisher syndrome is a useful diagnostic marker (Paparounas, 2004). It has been found that GQ1b ganglioside contributes to synaptic transmissions and synapse formation. Low concentrations of GQ1b ganglioside, evoked dopamine (DA) release from laboratory tissues (Chen, 2018).
    
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- Properties
  - Categories
    
    Ganglioside Oligosaccharides and Gangliosides
    
    CAS Number
    
    68652-37-9
    
    Molecular Formula
    
    C106H182N6O56·xNH4
    
    Note
    
    There is no hazardous surcharge associated with this product.
    There is no special packaging charge associated with this product.
    
    * For research use only. Not for human or veterinary use
- Reference
  - Ledeen et al (2009) Neurobiology Meets Glycosciences, In: The Sugar Code (Ed: Gabius H. J), pp 495-516, Wiley-VCH, Weinheim
    Paparounas (2004) Anti-GQ1b Ganglioside Antibody in Peripheral Nervous System Disorders Pathophysiologic Role and Clinical Relevance, Archives of Neurology, 61(7), 1013-1016.
    Chen et al (2018) Ganglioside GQ1b induces dopamine release through the activation of Pyk2, The Federation of American Societies for Experimental Biology, 32, lb610-lb610.