Name: GA2-Ganglioside
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- Overview
  - GA2-ganglioside is an asialo glycosphingolipid, also known as asialo-GM2 ganglioside. GA2 ganglioside accumulates in the cells of individuals with Sandhoff disease, a lysosomal storage disorder where β-hexosaminase is dysfunctional and unable to break down GA2 ganglioside to lactosylceramide (LacCer) (Sandhoff, 1968); a possible treatment for Sandhoff disease is substrate reduction therapy (Marshall, 2019).
    
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- Properties
  - Categories
    
    Ganglioside Oligosaccharides and Gangliosides
    
    Alternative Name
    
    Asialoganglioside-GM2;Gangliotriosyl ceramide;GgOse3Cer;b-GalNAc-(1?4)-b-Gal-(1?4)-b-Glc-(1?1)-Cer
    
    CAS Number
    
    35960-33-9
    
    Molecular Formula
    
    C56H104N2O18
    
    Molecular Weight
    
    1,093.43 g/mol
    
    MDL Number
    
    MFCD00131129
    
    Note
    
    There is no hazardous surcharge associated with this product.
    There is no special packaging charge associated with this product.
    
    * For research use only. Not for human or veterinary use
- Reference
  - Marshall et al (2019), Substrate Reduction Therapy for Sandhoff Disease through Inhibition of Glucosylceramide Synthase Activity, Molecular Therapy, 27(8),1495-1506,
    Sandhoff et al (1968), Deficient hexosaminidase activity in an exceptional case of Tay-Sachs disease with additional storage of kidney globoside in visceral organs, Life Sciences, 7(6), 283-288,