EZ Cap™ Human p53 mRNA

Human p53 mRNA with Cap 1 structure, providing higher transcription efficiency and enhanced stability.

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Background

p53 is one of the most studied transcription factors. p53 can activate its downstream genes in response to carcinogenic signals, such as apoptosis promoting protein BAX, p53 upregulates apoptosis regulator PUMA, etc. p53 also acts as a cell cycle checkpoint protector to induce cell cycle arrest and participate in DNA replication and repair to protect genomic integrity.
Synthetic mRNA delivery of p53 tumor suppressor function to cancer cells enables combination drug therapy. EZ Cap™ Human p53 mRNA is provided at a concentration of 1mg/ml. It is co-transcriptional capped which generates a cap 1 structure with high efficiency. Cap 1 structure is more ideal for mammalian systems and possesses higher transcription efficiency than Cap 0 structure (ARCA and mCap). The addition of poly (A) tail increases the stability and lifetime of the mRNA in vitro and in vivo. Poly (A) tail also plays an important role in enhancing the efficiency of translation initiation.