EZ Cap™ Human PTEN mRNA

Human PTEN mRNA with Cap 1 structure, providing higher transcription efficiency and enhanced stability.

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Background

PTEN (deletion of phosphatase and tensin homologues on chromosome 10) is a tumor suppressor gene that resists the action of PI3K, which is a key enzyme for anti-apoptotic, pro-tumorigenic Akt activation.
EZ Cap™ Human PTEN mRNA is provided at a concentration of 1mg/ml. It is co-transcriptional capped which generates a cap 1 structure with high efficiency. Cap 1 structure is more ideal for mammalian systems and possesses higher transcription efficiency than Cap 0 structure (ARCA and mCap). The addition of poly (A) tail increases the stability and lifetime of the mRNA in vitro and in vivo. Poly (A) tail also plays an important role in enhancing the efficiency of translation initiation.