EZ Cap™ Human p53 mRNA (ψUTP)

Human p53 mRNA with Cap 1 structure, modified by ψUTP, providing higher transcription efficiency and suppressing RNA-mediated innate immune activation.

Please contact us at for specific academic pricing.

Background

p53 is one of the most studied transcription factors. p53 can activate its downstream genes in response to carcinogenic signals, such as apoptosis promoting protein BAX, p53 upregulates apoptosis regulator PUMA, etc. p53 also acts as a cell cycle checkpoint protector to induce cell cycle arrest and participate in DNA replication and repair to protect genomic integrity.
Synthetic mRNA delivery of p53 tumor suppressor function to cancer cells enables combination drug therapy. EZ Cap™ Human p53 mRNA (ψUTP) is provided at a concentration of 1mg/ml. It is co-transcriptional capped which generates a cap 1 structure with high efficiency. Cap 1 structure is more ideal for mammalian systems and possesses higher transcription efficiency than Cap 0 structure (ARCA and mCap). ψUTP and poly (A) tail suppress RNA-mediated innate immune activation and increase the stability and lifetime of the mRNA in vitro and in vivo. Poly (A) tail also plays an important role in enhancing the efficiency of translation initiation.