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Erlotinib hydrochloride [CAS 183319-69-9]

Erlotinib hydrochloride [CAS 183319-69-9]

Catalog Number:

CR04341427TOK

Mfr. No.:

TOK-E017

Price:

$265

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- Overview
  - Erlotinib hydrochloride is a drug used to treat non-small cell lung cancer, pancreatic cancer and several other types of cancer. It is a tyrosine kinase inhibitor, which acts on the epidermal growth factor receptor (EGFR).
    
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    Background
    
    Erlotinib is an epidermal growth factor receptor (EGFR) inhibitor. Erlotinib specifically targets the EGFR tyrosine kinase ATP binding site, which is highly expressed and occasionally mutated in various forms of cancer. Erlotinib prevents EGFR homodimer formation, a conformational change required for signal transmittance.
- Properties
  - CAS Number
    
    183319-69-9
    
    Molecular Formula
    
    C22H23N3O4
    
    Molecular Weight
    
    393.43
    
    Appearance
    
    White or off-white powder
    
    Solubility
    
    Water: Very slightly soluble Acid (pH 2): 0.4 mg/mL Note: Maximum solubility can be attained by plain water at 0.8 mg/mL
    
    Other Properties
    
    Source: Synthetic
    Assay: 98.0-101.0%
    Loss on Drying: ≤0.5%
    Melting Point: 223-228 °C
    
    Storage
    
    2-8 °C
    
    * For research use only

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