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Overview
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Dihydronovobiocin is a semi-synthetic member of the novobiocin aminocoumarin antibiotic family prepared by reduction of the prenyl double bond and published in 1956. Dihydronovobiocin is an inhibitor of the bacterial type II topoisomerase, DNA gyrase. Dihydronovobiocin is equipotent to novobiocin against S. aureus in vivo, including resistant strains, and is active against Mycobacterium tuberculosis. Dihydronovobiocin entered clinical development in the 1960s but did not progress to market.
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