Cy7.5 carboxylic acid (non-sulfonated)

- Overview
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    Background
    
    Cy7.5 carboxylic acid is a free un-activated NIR dye which has low aqueous solubility. As for coupling and labeling reactions, pre-activated Cy7 NHS ester or water-soluble sulfo-Cy7 NHS ester would be considered. For biomolecule labeling, the labeling regent has low aqueous solubility, using of organic co-solvent to dissolve this molecular is necessary for efficient reaction. First, Cyanine dye should be dissolved in organic solvent and then added to a solution of biomolecule in appropriate aqueous buffer. In mice, near-infrared labeling of the materials allowed for non-invasive imaging of the injected hydrogel. Cy7.5 carboxylic acid labeled images can demonstrate localization of the injected hydrogel to the affected kidney. Moreover, the methodology allowed direct quantification of material degradation in vivo [1].
    
    Reference: [1]. Rodell, C.B.; Rai, R.; Faubel, S.; Burdick, J.A.; Soranno, D.E. Local Immunotherapy via Delivery of Interleukin-10 and Transforming Growth Factor β Antagonist for Treatment of Chronic Kidney Disease. Journal of Controlled Release, 2015, 206, 131–139.
- Properties
  - Categories
    
    Non-reactive fluorophore, for control experiments, and for calibration
    
    Alternative Name
    
    6-[(2E)-1,1-dimethyl-2-[(2E)-2-[3-[(E)-2-(1,1,3-trimethylbenzo[e]indol-3-ium-2-yl)ethenyl]cyclohex-2-en-1-ylidene]ethylidene]benzo[e]indol-3-yl]hexanoic acid
    
    Molecular Formula
    
    C45H49ClN2O2
    
    Molecular Weight
    
    685.34
    
    Purity
    
    98.00%
    
    Solubility
    
    soluble in organic solvents (DMSO, DMF, dichloromethane), low solubility in water
    
    Storage
    
    24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light
    
    SMILES
    
    CC1(C(=[N+](C2=C1C3=CC=CC=C3C=C2)C)C=CC4=CC(=CC=C5C(C6=C(N5CCCCCC(=O)O)C=CC7=CC=CC=C76)(C)C)CCC4)C
    
    * For Research Use Only