Chlortetracycline

- Overview
  - Chlortetracycline was the first reported member of the tetracycline class, isolated from Streptomyces aureofaciens in 1948. Chlortetracyclines heralded the early wave of antibiotic discoveries from microbes and after 50 years are still widely used as pharmaceuticals. Chlortetracycline is a pigment and, like most pigments, is extremely sensitive to environmental and storage conditions. Commercial chlortetracycline may contain significant levels of degradation products.
    
    Chlortetracycline is soluble in ethanol, methanol, DMF and DMSO.
    
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    Background
    
    The mechanism of chlorotetracycline involves entering a cell and binding to the 30s ribosomal subunit preventing peptide elongation and ultimately inhibiting protein synthesis. Resistance to chlorotetracycline can be a result of inactivation by cell enzymes or pumping the antibiotic out of the cell upon entering.
- Properties
  - CAS Number
    
    57-62-5
    
    Molecular Formula
    
    C22H23ClN2O8
    
    Molecular Weight
    
    478.9
    
    Appearance
    
    Yellow solid
    
    Storage
    
    -20°C
    
    * For research use only