Ceftizoxime Sodium

Ceftizoxime Sodium

Catalog Number:
M001342330TOK
Mfr. No.:
TOK-C021
Price:
$285
  • Size:
    1 g
    Quantity:
    Add to Cart:
      • Overview
        • Ceftizoxime Sodium is a third-generation cephalosporin with antibacterial activity similar to cefotaxime and moxalactam. It is not hydrolyzed by common plasmid and chromosomal β-lactamases. Ceftizoxime Sodium is soluble in aqueous solution.

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          Background

          Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid-encoded β-lactamases; however, ceftizoxime is stable in the presence of these inactivating enzymes.

      • Properties
        • CAS Number
          68401-82-1
          Molecular Formula
          C13H12N5O5S2 • Na
          Molecular Weight
          405.38
          Appearance
          White or pale yellow crystalline powder
          Solubility
          Soluble in aqueous solution
          Other Properties
          Source: Synthetic
          Water Content (Karl Fischer): ≤8.5%
          PH: 6.0-8.0
          Assay: (On Dried Basis): 850-995 µg/mg
          Optical Rotation: +125° to +145°
          Storage
          -20°C

          * For research use only

      • Applications
        • Application Description
          Spectrum: Ceftizoxime is a broad-spectrum antibiotic targeting a wide variety of Gram-positive and Gram-negative bacteria, both aerobic and anaeobic.

          Microbiology Applications: Ceftizoxime Sodium is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive and Gram-negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options. Representative MIC values include: Haemophilus spp. 0.008 µg/mL – 0.25 µg/mL Neisseria spp. 0.004 µg/mL – 0.015 µg/mL Eukaryotic Cell Culture Applications: The effect of cephalosporins on in vitro growth of lymphocytes were studied using L 5178y mouse lymphoma cells, Molt-4 cells, and murine splenic lymphocytes. Ceftizoxime had no effect on growth of Molt-4 cells at levels of 0.3 to 50 uM and no effect on L 5178y mouse lymphoma cells at 0.1 and 50 µM. The levels of the three polymerases were studied (DNA polymerase α and β, terminal deoxynucleotidyl transferase (TdT) activity) . DNA polymerase β is the major repair polymerase and its activity remains constant in the different cell stages whereas the DNA-replicating DNA polymerase α activity increases at the beginning of S-phase. The TdT, a marker enzyme for immature lymphocytes in the hematopoietic system, reflects the differentiation state of bone marrow pre-T and pre-B cells. The levels of the three polymerases remained unchanged in Molt-4 cells after incubating them with Ceftizoxime (0.1 to 80 µM )(Leyhausen et al, 1984).

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