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Overview
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Ceftizoxime Sodium is a third-generation cephalosporin with antibacterial activity similar to cefotaxime and moxalactam. It is not hydrolyzed by common plasmid and chromosomal β-lactamases. Ceftizoxime Sodium is soluble in aqueous solution.
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Background
Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid-encoded β-lactamases; however, ceftizoxime is stable in the presence of these inactivating enzymes.
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- Properties
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Overview