Name: Cefsulodin Sodium
Price: 163.00 USD

- Overview
  - Cefsulodin Sodium is a third-generation cephalosporin antibiotic. Our scientists have found that the primary cause of Cefsulodin instability is due to a key impurity in one of the materials used in Cefsulodin synthesis, 7-aminocephalosporanic acid (7-ACA). In order to produce highly pure and Cefsulodin with high stability, industrial HPLC is used to remove significant quantities of this impurity for improved purity, potency, and stability.
    Cefsulodin is also used in Coronavirus (SARS-CoV-2) research for compound repurposing campaigns. In silico screening of 2421 approved small molecules and molecular dynamics simulations at Coventry University has revealed that Cefsulodin can bind to the SARS-CoV-2 S glycoprotein receptor binding domain (RBD).
    
    Please contact us at for specific academic pricing.
    
    Background
    
    Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases.
- Properties
  - CAS Number
    
    52152-93-9
    
    Molecular Formula
    
    C22H19N4NaO8S2 · xH2O
    
    Molecular Weight
    
    554.53 (Anhydrous basis)
    
    Appearance
    
    White or light yellow crystalline powder
    
    Solubility
    
    Freely soluble in water
    
    Other Properties
    
    Source: Synthetic
    Water Content (Karl Fischer): ≤5.0%
    PH: 3.3-4.8
    Assay: (On Dried Basis): ≤90.0%
    Melting Point: 175°C
    Optical Rotation: +16.5° to 20.0°
    
    Storage
    
    -20°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Cefsulodin Sodium has a very limited spectrum, specifically targeting Pseudomonas aeruginosa.
    
    Microbiology Applications: Cefsulodin Sodium is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) primarily against Pseudomonas aeruginosa. Medical microbiologists use AST results to recommend antibiotic treatment options.
    One line of SARS-CoV-2 research involves disrupting the entrance of the coronavirus into host cells. Researchers at Coventry University found that Cefsulodin can bind to the SARS-CoV-2 S glycoprotein receptor binding domain (RBD) in silico. The S glycoprotein gives the coronavirus SARS-CoV-2 it's 'crown' phenotype by forming prominent structures on the virion envelope. The spike protein mediates the first interactions with the host cell and drives virulence and induces immune responses. THe S glycoprotein has 2 subunits (S1 and S2). S1 comprises the receptor -binding domain (RBD) for the antiotensin-converting enzyme 2 (ACE2). S2 drives the fusion along with the human antiotensin-converting enzyme (ACE2).
    Media Supplements
    Cefsulodin can be used as a selective agent in several types of isolation media:
    Yersinia Selective Agar - Yersinia Selective Supplement
    Columbia Blood Agar - Helicobacter pylori Selective Supplement (Dent)
    mTSB - VCC Selective Supplement
    Salmonella Chromogenic Agar - Salmonella Selective Supplement