Caerulein

Caerulein is a gastric regulatory molecule similar in function and composition to cholecystokinin (CCK), which stimulates gastric, bile duct and pancreatic secretion. Cerulein can be used to study signal transduction pathways mediated by NF-κB up-regulated proteins such as intercellular adhesion molecule (ICAM-1), inflammation-related factors such as NADPH oxidase, and Janus kinase. It has been successfully used in the establishment of acute pancreatitis (AP) models in animals such as rats, mice, dogs, and Syrian hamsters [1-5]. The modeling mechanism is:
1) Up-regulation of pancreatic acinar by stimulating intracellular NF-κB Intracellular Intercellular Adhesion Molecule (ICAM-1) expression. Surface ICAM-1 in turn promotes neutrophil adhesion to acinar cells to enhance pancreatic inflammatory effects [6];
2) leads to acinar cell death and pancreatic edema by inducing dysregulated digestive enzyme secretion and cytoplasmic vacuolation, thereby inducing pancreatitis;
3) Activating inflammation-promoting factors [7].
Cerulein can be used to prevent gallbladder pain, renal colic, and intermittent claudication pain. It is generally considered to be an antagonist of endorphins. LPS can be used in conjunction with caerulein to establish a pancreatitis animal model.
This product is in the form of a decapeptide molecule, the polypeptide sequence is pGlu-Gln-Asp-Tyr(SO3H)-Thr-Gly-Trp-Met-Asp-Phe-NH2 (or Glp-Gln-Asp-Tyr(SO3H)-Thr-Gly-Trp-Met-Asp-Phe-NH2).

Please contact us at for specific academic pricing.