BSA-MMAE Conjugate

MMAE (monomethyl auristatin E) is an antimitotic agent that binds to tubulin and inhibits the assembly of microtubules. Mc-VC-PAB-MMAE is a thiol reactive derivative of MMAE that contains a cathepsin cleavable valine-citruline p-aminobenzylcarbamate linkage. Mc-VC-PAB-MMAE is used to prepare antibody-drug conjugates, such as brentuximab vedotin (Seattle Genetics). This BSA-MMAE conjugate is designed with similar linker chemistry as ADCs synthesized for our customers' usage in immunization or immunoassay. Thiol functional groups are introduced to the BSA followed by reaction of the maleimide group of Mc-VC-PAB-MMAE to form the conjugate.

The final conjugate is lyophilized from phosphate buffered saline containing sugar-based stabilizer for easy shipping and storage.

The product is sold as 1 vial of 1 mg (Cat# CM52113-1MG) or 5 vials of 1 mg (Cat# CM52113-5MG).

• Chemical Information
Chemical name: BSA-MMAE (monomethyl auristatin E) Conjugate
Chemical formula: N/A
Molecular weight: ~71KDa CAS number: N/A

• Specification
Physical appearance: white to off-white preservative-free lyophilized powder in a 2.0 mL centrifuge tube
Storage temp.:≤-20°C for lyophilized powder. After reconstitution, the stock solution can be used up to 1 week if stored at 2-8°C.
Purity: ≥ 99% of conjugates by HPLC
Drug over BSA ratio: ~4 by MALDI-TOF MS

Please contact us at for specific academic pricing.