Bilastine

- Overview
  - Bilastine is a second-generation antihistamine used for allergic rhinoconjunctivitis and urticaria (hives). Bilastine also has anti-inflammatory activity.
    
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    Background
    
    Bilastine, a novel molecule, is a selective histamine H1 receptor antagonist. It is a substrate for P-glycoprotein, a membrane pump
- Properties
  - Categories
    
    BioActive Small Molecules
    
    CAS Number
    
    202189-78-4
    
    Molecular Formula
    
    C28H37N3O3
    
    Molecular Weight
    
    463.61
    
    Appearance
    
    White crystalline powder
    
    Solubility
    
    Soluble in DMSO
    
    Other Properties
    
    Source: Synthetic
    Purity Level: >98% (HPLC)
    
    Storage
    
    -20°C
    
    * For research use only
- Applications
  - Application Description
    
    Eukaryotic Cell Culture Applications: Bilastine binds to histamine H1-receptors as indicated by its displacement of [3H]-pyrilamine from H1-receptors expressed in guinea-pig cerebellum and human embryonic kidney (HEK) cell lines. Bilastine is selective for histamine H1-receptors as shown in receptor-binding screening with 30 different receptors. The specificity of its H1-receptor antagonistic activity was also demonstrated in a series of in vitro experiments with guinea-pig and rat tissues. Bilastine also has anti-inflammatory activity as demonstrated in vitro with the Schultz-Dale reaction (Corcóstegui et al, 2005).