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Overview
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4-Epitetracycline ammonium salt, EvoPure® is a highly purified version of 4-Epitetracycline, an epimer of Tetracycline. Tetracycline is a broad-spectrum antibacterial and selection agent.
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Background
Under acid conditions, Tetracycycline undergoes a reversible epimerization at the fourth carbon, producing a mixture of tetracycline and 4-Epitetracycline. Tetracycline inhibits the growth of Gram-positive and Gram-negative bacteria by disrupting codon-anticodon interactions at the ribosome, thus blocking protein synthesis. Specifically, Tetracycline binds to the 30S ribosomal subunit and blocks the attachment of charged aminoacyl-tRNA to the A site on the ribosome, preventing peptide elongation.
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- Properties
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Overview