Name: BAM (8-22)
Price: 331.00 USD

- Overview
  - Potent agonist of sensory neuron specific receptors.
    BAM (8-22), also known as bovine adrenal medulla 8-22, is an endogenous peptide that was first isolated from bovine adrenal medulla and is a potent agonist for sensory neuron specific receptors, primate-specific proteins that are exclusively expressed in primary sensory neurons, with EC50 values of 28 and 14 nM for SNSR3 and SNSR4 respectively. BAM (8-22) inhibits development of morphine tolerance in rats and exerts spinal analgesic effects by an interaction with NMDA receptors. It also blocks inflammatory pain, chemical pain and downregulates the expression of spinal c-fos gene in an opioid-independent manner. In humans BAM (8-22) produces itch and nociceptive sensations in a histamine independent manner.
    
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- Properties
  - Categories
    
    Peptides
    
    Alternative Name
    
    Bovine adrenal medulla (8-22)
    
    Molecular Formula
    
    C91H127N25O23S
    
    Molecular Weight
    
    1971.2
    
    Appearance
    
    Freeze dried sold
    
    Purity
    
    >95% by HPLC
    
    Solubility
    
    Soluble to 1 mg/ml in water
    
    Other Properties
    
    Sequence: H-Val-Gly-Arg-Pro-Glu-Trp-Trp-Met-Asp-Tyr-Gln-Lys-Arg-Tyr-Gly-OH,VGRPEWWMDYQKRYG
    
    Storage
    
    Store desiccated, frozen and in the dark
    
    * Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

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