Name: BAM 22P
Price: 461.00 USD

- Overview
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    Background
    
    IC50: 1.3 nM for opiate activityBovine adrenal medulla 22 peptide (BAM22P) is a peptide with 22 amino acids which is one of the cleavage products of proenkephalin A, the precursor of Leu- and Met-enkephalin, in the adrenal medulla, with very potent opiate activity. In vitro: In the guinea-pig ileum assay, BAM-22P has been shown to have typical and extraordinarily potent opioid activities antagonized by naloxone. The potency of BAM-22P is 26 times that of Met-enkephalin and 22 times that of B hendorphin. IC50 value of BAM-22P in this tissue, 1.3 nM, makes it the most potent Met-enkephalin relatives that discoveried so far. [1]. In vivo: Intrathecal (i.t.) administration of BAM22 decreased nocifensive behavior scores, which measured as the sum of flinching and lifting/licking, in the first and second phases of the formalin test. Such decrease was partially attenuated by systemic injection of naloxone. [2]. Clinical trial: Up to now, BAM 22P is still in the preclinical development stage.
    
    [1] Mizuno K, Minamino N, Kangawa K, Matsuo H. A new family of endogenous "big" Met-enkephalins from bovine adrenal medulla: purification and structure of docosa- (BAM-22P) and eicosapeptide (BAM-20P) with very potent opiate activity. Biochem Biophys Res Commun. 1980 Dec 31;97(4):1283-90.
    [2] Hong Y, Dai P, Jiang J, Zeng X. Dual effects of intrathecal BAM22 on nociceptive responses in acute and persistent pain--potential function of a novel receptor. Br J Pharmacol. 2004 Feb;141(3):423-30.
- Properties
  - Categories
    
    Potent endogenous agonist peptide for the newly identified sensory neuron specific receptor (SNSR);
    
    Alternative Name
    
    (3Z,5S,6Z,8S,9Z,11S,12Z,14S,15Z,17S,18Z,20S,21Z,23S,24Z,26S,27Z,29S,30Z,32S)-26,29-bis((1H-indol-3-yl)methyl)-32-((Z)-(((S)-1-((2S,3Z,6Z,8S,9Z,11S,12Z,14S,15Z,17S,18Z,20S,21Z,24Z,27Z,29S)-29-amino-20-benzyl-2,11,14-tris(3-guanidinopropyl)-4,7,10,13,16,19,
    
    CAS Number
    
    76622-26-9
    
    Molecular Formula
    
    C130H184N38O31S2
    
    Molecular Weight
    
    2839.22
    
    Appearance
    
    White lyophilised solid
    
    Purity
    
    98.00%
    
    Solubility
    
    Soluble to 1 mg/ml in H2O
    
    Storage
    
    Desiccate at -20°C
    
    SMILES
    
    CC([[email protected]@](/N=C(O)/[[email protected]](/N=C(O)/[[email protected]](/N=C(O)/[[email protected]](/N=C(O)/[[email protected]](/N=C(O)/C/N=C(O)/C/N=C(O)/[[email protected]](N)([H])CC1=CC=C(O)C=C1)([H])CC2=CC=CC=C2)([H])CCSC)([H])CCCNC(N)=N)([H])CCCNC(N)=N)([H])/C(O)=N/C/C(O)=N/[[email protected]@](C(N3CCC[[email protected]@]3([H])/C(O)=N/[[email protected]@](/C(O)=N/[[email protected]@](/C(O)=
    
    * For Research Use Only

Documents

COA (Certificate Of Analysis)

MSDS (Material Safety Data Sheet)

Datasheet

BAM 22P

BAM 22P

Background

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