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AS-8351

AS-8351

Catalog Number:

I001528188REA

Mfr. No.:

EI-DEM-008

Price:

$270

Size:

5 mg

Quantity:

Add to Cart:

- Overview
  - 2-Hydroxy-1-naphthylaldehyde isonicotinoylhydrazone; NSC-51355
    
    AS-8351 has been used in a cocktail of nine small molecules used to efficiently induce cardiac reprogramming of human fibroblasts1. It is believed that AS-8351exerts its effects by modulating the activity of the JmjC domain-containing histone demethylases (JmjC-KDM). Thus each of the 22 genes in the JmjC-KDM family was abrogated using small hairpin RNAs which showed that only knocking down KDM5B (or using another KDM5B inhibitor such as PBIT) could phenocopy AS-8351 in generating cardiomyocytes.
    
    Please contact us at for specific academic pricing.
- Properties
  - Molecular Formula
    
    C17H13N3O2
    
    Molecular Weight
    
    MW=291.3
    
    Appearance
    
    Yellow powder
    
    Solubility
    
    Solubilization: May be dissolved in DMSO (45 mg/ml); or ethanol (10 mg/ml, warm); or DMF (30 mg/ml)
    
    Storage
    
    Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 1 month.
    
    * For Research Use Only.
- Applications
  - Application
    
    Epigenetic Inhibitors

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