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Overview
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1H-?b-?D-?ribofuranosyl-?2-?pyrimidinone; NSC 309132
DNA methyltransferase inhibitor which binds covalently to methyltransferases. Re-activates silenced E-cadherin expression in EBV-harboring Burkitt's lymphoma Akata cells. Delays tumor growth and induces apoptosis in a genetically engineered mouse model of breast cancer. Potentiates differentiation of mesenchymal stem cells into cardiomyocytes. Inhibits cytidine deaminase (Ki ~ 2 µM). Active in vivo.Please contact us at for specific academic pricing.
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