APPBP1/6xHis-UBA3

Catalog Number:
EUAE097620UBP
Mfr. No.:
B1401
Price:
$584
  • Size:
    100 µg
    Quantity:
    Add to Cart:
      • Overview
        • APPBP1/UBA3 is the heterodimeric E1 enzyme that conjugates Nedd8 to protein substrates. Nedd8 is conjugated onto the catalytic cysteine residue of UBA3 by formation of a thioester bond in an ATP-dependent reaction. The activated Nedd8 is then passed on to an E2 (Ubc12) to be finally attached to a substrate. Nedd8 is mainly conjugated on Cullins to increase the activity of the Cullin – RING E3 Ub ligases.

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      • Properties
        • Source
          Bacterial recombinant
          Formulation
          20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol
          Storage
          Store at -80°C; avoid multiple freeze-thaw cycles
          Concentration
          See tube label
          Molecular Weight
          APPBP1 (60.2 kDa), UBA (51.8 kDa)

          * Research Use Only

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