Name: Anti-TYMS antibody
Price: 331.00 USD

Overview
- TS (EC:2.1.1.45), a cytosolic enzyme, is a dimmer of two identical monomers of about 36kDa. The enzyme provides the sole intracellular de novo source of thymidylate and plays a crucial role in DNA replication and repair. TS catalyzes the methylation of deoxyuridine monophosphate (dump) and its conversion to deoxythymidine monophosphate (dTMP). Therefore, TS is primarily active in proliferating and metabolic active cells. TS is a central target of the widely used antineoplastic agent 5‐Fluorouracil (5‐FU) and thus also of the Xeloda, which is enzymatically activated to 5‐FU. TS is inactivated by a covalent complex formation with 5‐FdUMP and methylenetetrahydrofolate. Literature indicates that expression of TS is associated with response to 5‐fluorouracil (5‐FU) in human breast, colorectal, gastric, head, and neck carcinomas with low TS expression predicting better response to 5‐FU and survival.
  
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Properties
- Host
  
  mouse
  
  Antibody Type
  
  monoclonal
  
  Isotype
  
  IgG1 kappa
  
  Reactivity
  
  human
  
  Clone
  
  TS106
  
  Immunogen
  
  Recombinant human thymidylate synthase
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  Purified antibody diluted in Tris‐HCI buffer containing stabilizing protein and <0.1% sodium azide.
  
  Storage
  
  Store at 2-8°C for up to 1 year
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Thymidylate Synthase; Ts; Tsase (Gene ID:7298; UniProt:P04818)
  
  * For research use only