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Overview
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Tyrosinase is a copper‐containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway; the hydroxylation of tyrosine to L‐3, 4‐ dihydroxyphenylalanine (dopa), and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T‐cell recognition in melanoma patients. Clone T311 shows no cross‐reaction with MAGE‐1 and tyrosinase‐related protein 1, TRP‐1/gp75.1 Staining of melanomas with clone T311 showed tyrosinase in melanotic as well as amelanotic variants.1 Ab‐1 is a useful marker for melanocytes and melanomas. Occasionally a minor band at 55kDa is also detected in Western Blotting.
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