Name: Anti-TP63 antibody
Price: 358.00 USD

Overview
- p63 is a homolog of the tumor suppressor p53. It is identified in basal cells in the epithelial layers of a variety of tissues, including epidermis, cervix, urothelium, breast and prostate. p63 was detected in nuclei of the basal epithelium in normal prostate glands; however, it was not expressed in malignant tumors of the prostate. As a result, p63 has been reported as a useful marker for differentiating benign from malignant lesions in the prostate, particularly when used in combination with markers of high molecular weight cytokeratins and the prostate-specific marker AMACR (P504S). p63 has also been shown to be a sensitive marker for lung squamous cell carcinomas (SqCC), with a sensitivity of ~90%. Specificity for lung SqCC, vs. lung adenocarcinoma (LADC), is approximately 80%. In breast tissue, p63 has been identified in myoepithelial cells of normal ducts.
  
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Properties
- Host
  
  mouse
  
  Antibody Type
  
  monoclonal
  
  Isotype
  
  IgG2a kappa
  
  Reactivity
  
  human; mouse; rat
  
  Clone
  
  4A4
  
  Immunogen
  
  Recombinant full-length human p63 protein
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  Culture supernatant in Tris-HCI buffer containing stabilizing protein and <0.1% sodium azide.
  
  Storage
  
  Store at 2-8°C for up to 1 year
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Tumor Protein 63; P63; Chronic Ulcerative Stomatitis Protein; Cusp; Keratinocyte Transcription Factor Ket; Transformation-Related Protein 63; Tp63; Tumor Protein P73-Like; P73l; P40; P51 (Gene ID:8626; UniProt:Q9H3D4)
  
  * For research use only