Anti-PAX8 antibody

Catalog Number:
STJ180214
Price:
$732
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      • Overview
        • PAX‐8 is expressed in the thyroid, non‐ciliated mucosal cells of the fallopian tubes and simple ovarian inclusion cysts, but not normal ovarian surface epithelial cells. PAX‐8 is expressed in ovarian serous, endometrioid, and clear cell carcinomas, but only rarely in primary ovarian mucinous adenocarcinomas. Over 98% of clear cell RCCs, 90% of papillary RCCs, and 95% of oncocytomas were positive for PAX‐8. Similarly, the absence of expression of PAX‐8 in breast and other non‐GYN carcinomas other than those primary to the thyroid indicates that PAX‐8 is an important new marker of ovarian cancer and a useful marker for the differential diagnoses in lung and neck tumors, or tumors at distant sites where primary lung carcinoma or thyroid carcinoma are possibilities. PAX‐8, combined with organ system‐specific markers such as uroplakin, mammaglobin, and TTF‐1 can be a very useful panel to determine the primary site of invasive micropapillary carcinomas of ovary from bladder, lung, and breast. Unlike the polyclonal anti‐PAX‐8 antibody, the ZR1 rabbit monoclonal antibody does not react with pancreatic neuroendocrine tumors, thymic tumors, and lymphocytes.

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      • Properties
        • Host
          rabbit
          Antibody Type
          monoclonal
          Isotype
          IgG
          Reactivity
          human
          Clone
          ZR1
          Immunogen
          Synthetic peptide corresponding to the C‐ terminus of Human PAX8 protein
          Conjugate
          Unconjugated
          Formulation
          Purified antibody diluted in Tris‐HCI buffer containing stabilizing protein and <0.1% sodium azide.
          Storage
          Store at 2-8°C for up to 1 year
          Regulatory Status
          RUO

          * For research use only

      • Applications
        • Application
          IHC (paraffin)
        • Application Dilutions
          IHC (paraffin) 1:50‐100
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