Anti-CD274 antibody

Overview
- Programmed cell death ligand 1 (PD‐L1) also known as cluster of differentiation (CD274) or B7 homolog1 (B7‐H1) is a type 1 transmembrane protein involved in the regulation of cellular and humoral immune responses. The interaction of PD‐L1 with its receptor PD‐1 provides both stimulatory and inhibitory signals in regulating T cell activation and tolerance during pregnancy, tissue allografts, autoimmune disease andmalignant transformation. The binding of PD‐L1 to PD‐1 induces apoptosis or exhaustion in activated T cells, and blockade of this interaction has been shown to enhance the antitumor activity ofT cells. PD‐L1 is frequently over expressed in placenta, and many human tumors such as melanoma, diffuse large B‐cell lymphoma, and carcinomas of the lung, bladder, breast, kidney and colon.
  
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Properties
- Host
  
  rabbit
  
  Antibody Type
  
  monoclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human
  
  Clone
  
  ZR3
  
  Immunogen
  
  KLH‐conjugated linear peptide corresponding to human PD‐L1
  
  Conjugate
  
  KLH
  
  Formulation
  
  Purified antibody diluted in Tris‐HCI buffer containing stabilizing protein and <0.1% sodium azide.
  
  Storage
  
  Store at 2-8°C for up to 1 year
  
  Regulatory Status
  
  RUO
  
  * For research use only