Name: Anti-TLR3 antibody
Price: 673.00 USD

Overview
- Recognizes the 116 kDa human Toll-like receptor 3 (TLR3, CD283). Toll-like receptors (TLRs)are highly conserved from Drosophila to humans and share structural and functional similarities. TLRsconstitute of a family of pattern recognition receptors (PRRs) that mediate cellular responses to a largevariety of pathogens (viruses, bacteria, and parasites) by specific recognition of so-called 'pathogen-associated molecular patterns'. TLRs have a central role in innate immunity and are also required forthe development of an adaptive immune response. TLRs are expressed by various cells of the immunesystem, such as macrophages and dendritic cells. TLRs are class I receptors, with a single alpha-helix thatspans the cell membrane. They recognize and respond to molecules derived from bacterial, viral andfungal pathogens, such as lipopolysaccharide (LPS) from the outer membrane of Gram negativebacteria, peptidoglycan fragments from bacterial cell walls and single-stranded and double-strandedRNA from viruses.
  
  Please contact us at for specific academic pricing.
Properties
- Host
  
  mouse
  
  Antibody Type
  
  monoclonal
  
  Isotype
  
  IgG1
  
  Reactivity
  
  human
  
  Clone
  
  TLR3.7
  
  Conjugate
  
  Biotin
  
  Formulation
  
  50 µg purified antibody, conjugated to biotin, in Phosphate Buffered Saline containing0.1% BSA.
  
  Storage
  
  Store antibody at 2-8°C until expiry. Avoid prolonged exposure to light.
  
  Concentration
  
  0.1 mg/ml
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Toll-Like Receptor 3; Cd Antigen Cd283 (Gene ID:7098; UniProt:O15455)
  
  * For research use only