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Overview
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Was raised against intracellular fragment corresponding to aa 141-295 of human LIME, a 30kDa Lck-interacting transmembrane adaptor expressed by T cells. LIME (Lck-interacting molecule) is araft-associated adaptor protein involved in regulation of T cell activation by coreceptors. LIME becomestyrosine phosphorylated after cross-linking of the CD4 or CD8 coreceptors. Phospho-LIME associateswith the Src family kinase Lck and its negative regulator, Csk. Ectopic expression of LIME in Jurkat T cellsresults in an increase of Csk in lipid rafts, increased phosphorylation of Lck and higher Ca2+ responseto CD3 stimulation.Immunogen: Bacterially expressed intracellular fragment corresponding to aa 141-295 of human LIME.
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