Western blot analysis of extracts of various cell lines, using SETD2 antibody (STJ113752) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit.Exposure time: 5s.

Anti-SETD2 antibody

Catalog Number:

A001020876STJ

Mfr. No.:

STJ113752

Price:

$297

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Overview
- Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II.
  
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Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  mouse; rat
  
  Immunogen
  
  Recombinant fusion protein containing a sequence corresponding to amino acids 803-1103 of human SETD2 (NP_054878. 5).
  
  Purification
  
  Affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  
  Storage
  
  Store at -20°C and avoid freeze-thaw cycles.
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Histone-Lysine N-Methyltransferase Setd2; Hif-1; Huntingtin Yeast Partner B; Huntingtin-Interacting Protein 1; Hip-1; Huntingtin-Interacting Protein B; Lysine N-Methyltransferase 3a; Protein-Lysine N-Methyltransferase Setd2; Set Domain-Containing Protein 2; Hset2; P231hbp (Gene ID:29072; UniProt:Q9BYW2)
  
  * For research use only