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Overview
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Recognizes an epitope specific for the S100A8/A9 heterocomplex that is not exposed onthe individual subunits S100A8 (MRP8, calgranulin-A) or S100A9 (MRP14, calgranulin-B). The calcium-binding migration inhibitory factor-related proteins, MRP-8 (S100A8) and MRP-14 (S100A9) belong tothe S100 protein family. The expression of these proteins is largely confined to the cytosol ofneutrophils and monocytes. The complex formation of these proteins is a calcium-dependent process.The S100A8/A9 heterocomplex, also called MRP-8/MRP-14 complex or calprotectin, comprises 60% ofthe cytoplasmic protein fraction of circulating polymorphonuclear granulocytes and is also found inmonocytes, macrophages and ileal tissue eosinophils. Peripheral blood monocytes carry the antigenextra-and intracellularly, neutrophils only intracellularly. The S100A8/A9 complex has antibacterial, antifungal, immunomodulating and antiproliferative effects.Immunogen: Human blood monocytes
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