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Overview
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CD163, also known as scavenger receptor cysteine-rich type 1 protein M130, is an acute phase-regulated and signal-inducing transmembrane protein, found exclusively on cells of monocytic origin.CD163 plays a critical role in macrophage clearance and endocytosis of hemoglobin/haptoglobincomplexes. Therefore, CD163 contributes to the anti-inflammatory response and protects tissues fromoxidative and inflammatory hemoglobin. Anti-CD163 labels cells of monocytic-macrophage lineage, with expression in bone marrow3 and histiocytic neoplasms. Solubilized in plasma, CD163 functions asan anti-inflammatory signal and has many roles in disease processes that range from autoimmuneconditions such as rheumatoid arthritis to atherosclerosis.
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