Name: Anti-CD163 antibody
Price: 337.00 USD

Overview
- CD163 has been identified as an acute phase‐regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin‐hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti‐CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti‐CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti‐ CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue.
  
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Properties
- Host
  
  mouse
  
  Antibody Type
  
  monoclonal
  
  Isotype
  
  IgG2b kappa
  
  Reactivity
  
  human
  
  Clone
  
  ZM29
  
  Immunogen
  
  Recombinant human CD163 fragment (around aa 43‐196)
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  Purified antibody diluted in Tris‐HCI buffer containing stabilizing protein and <0.1% sodium azide.
  
  Storage
  
  Store at 2-8°C for up to 1 year
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Scavenger Receptor Cysteine-Rich Type 1 Protein M130; Hemoglobin Scavenger Receptor; Cd Antigen Cd163 Cleaved Into-Soluble Cd163; Scd163 (Gene ID:9332; UniProt:Q86VB7)
  
  * For research use only