Anti-PSAP antibody

Catalog Number:

A001034789STJ

Mfr. No.:

STJ25165

Price:

$297

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Overview
- This gene encodes a highly conserved preproprotein that is proteolytically processed to generate four main cleavage products including saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
  
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Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human; mouse; rat
  
  Immunogen
  
  Recombinant fusion protein containing a sequence corresponding to amino acids 60-310 of human PSAP (NP_002769. 1).
  
  Purification
  
  Affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  
  Storage
  
  Store at -20°C and avoid freeze-thaw cycles.
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Prosaposin; Proactivator Polypeptide Cleaved Into-Saposin-A; Protein A-Saposin-B-Val-Saposin-B; Cerebroside Sulfate Activator; Csact; Dispersin; Sphingolipid Activator Protein 1; Sap-1; Sulfatide/Gm1 Activator-Saposin-C; A1 Activator; Co-Beta-Glucosidase; Glucosylceramidase Activator; Sphingolipid Activator Protein 2; Sap-2-Saposin-D; Component C; Protein C (Gene ID:5660; UniProt:P07602)
  
  * For research use only