-
-
Overview
-
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.
Please contact us at for specific academic pricing.
-
- Properties
- Applications
-
Overview
Immunofluorescence analysis of L929 cells using PSEN1 Rabbit pAb (STJ25167) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
Immunofluorescence analysis of HeLa cells using PSEN1 Rabbit pAb (STJ25167) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
Immunohistochemistry of paraffin-embedded human liver using PSEN1 Rabbit pAb (STJ25167) at dilution of 1:100 (40x lens).
Immunofluorescence analysis of C6 cells using PSEN1 Rabbit pAb (STJ25167) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
Western blot analysis of extracts of U-87MG cells, using PSEN1 antibody (STJ25167) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit.Exposure time: 30s.
Anti-PSEN1 antibody
Anti-PSEN1 antibody
Catalog Number:
A001034790STJ
Mfr. No.:
STJ25167
Price:
$297
Size:
Quantity:
Add to Cart:
.